The Dodgers batted around in the third, when Hyeseong Kim singled in a run, Ohtani went deep to left-center and Andy Pages added a 416-foot, three-run shot with two outs for a 13-2 lead.
Ohtani tied Aaron Judge and Kyle Schwarber for the major league home run lead with his 15th in the fourth, a two-run, 418-foot blast to center for the 20th multi-homer game of his career.
Ohtani drove in one of the Dodgers' three runs with a sacrifice fly in the second. They scored three runs in the first, highlighted by Max Muncy's two-run homer. They tacked on another three runs in the eighth.
Kim reached base five times, twice via walk, and scored three runs.
Justin Wrobleski (1-1) got the win.
The Athletics had just three hits, including Max Schuemann's homer, and only one after the second inning.
Key moment
Ohtani struck out swinging on an 89-mph fastball from A's backup catcher Jhonny Pereda in the eighth. The A's saved the ball for Pereda, who was pitching for the third time this season.
Key stats
Ohtani has nine homers in his last 15 games and he leads the majors with 48 runs. ... Every Dodgers starter had at least one hit.
Up next
LH JP Sears (4-2, 2.80 ERA) starts for the Athletics on Friday at San Francisco. RH Dustin May (1-3, 4.13) starts the Dodgers' series opener against the Los Angeles Angels.
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AP MLB: https://apnews.com/hub/mlb
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